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Introduction
  • Classification
    • Bacteria
      • other Gram-negative
        • zoonotic
          • Francisella
            • F. tularensis
  • Pathogenesis
    • transmission
      • wild animal → ticks and deerflies → tick or deerfly bite
      • skinning rabbits
        • traumatic implantation
        • inhalation
      • contaminated meat
    • reservoir
      • wild animals
        • especially rabbits, deer, rodents
      • potential bioterrorism agent
    • molecular biology
      • facultative intracellular
        • replicates in macrophages
Diseases
  • Ulceroglandular tularemia
    • tick bite
    • black-colored hole in skin develops
    • lymph nodes become swollen, red, and painful
    • very similar presentation to bubonic plague
  • Pneumonic tularemia
    • pneumonia
    • from inhalation of organism or spread from skin
  • Oculoglandular tularemia
    • eye infection
  • Typhoidal tularemia
    • GI infection
Laboratory
  • Small Gram-negative rod
  • Diagnose with serology
    • culture is hazardous
Treatment
  • Streptomycin
 

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