|
Introduction
  • Classification
    • Bacteria
      • Gram-negative bacilli
        • aerobes
          • Pseudomonas
            • P. aeruginosa
  • Pathogenesis
    • transmission
      • nosocomial
      • water
      • raw vegetables
      • flowers
    • reservoir
      • water (ubiquitous)
    • molecular biology
      • pyocyanin and pyoverdin (blue and green pigment)
        • has a grapelike odor
      • exotoxin A
        • stops protein synthesis via inactivation of elongation factor 2 (EF-2)
          • via ADP ribosylation
        • same mechanism as diphtheria toxin
      • endotoxin
        • causes inflammation, fever, and shock
      • capsule/slime layer
        • evades phagocytosis
Diseases
  • "BE PSEUDO" most commonly affects the immunocompromised
    • Burns
    • Endocarditis
      • right valve in IV drug abusers
    • Pneumonia
      • in cystic fibrosis
      • in immunocompromised
      • ICU patients on respirator
        • productive cough with green sputum
    • Sepsis
      • ecthyma gangrenosum 
        • necrotic skin lesions
        • due to perivascular invasion and release of exotoxins
      • can occur from catheter infection
    • External otitis
      • swimmer's ear
      • malignant otitis externa in diabetics
    • UTI
      • especially with Foley catheters
    • Drug use
    • Osteomyelitis 
      • trauma (e.g. puncture wounds to foot)
      • diabetics
      • drug addicts
    • hot tub folliculitis 
      • superficial infection of the hair follicle due to exposure in a pool/hot tub/spa
    • corneal infections
      • in contact lens users
Laboratory
  • Non-lactose fermenting
  • Oxidase positive
Treatment
  • Aminoglycoside + extended-spectrum penicillin
  • Usually antibiotic resistant
 

Please rate topic.

Average 5.0 of 4 Ratings

Questions (4)
EVIDENCE & REFERENCES (4)
Topic COMMENTS (6)
Private Note