|
Overview
  • Atropine
    • blocks vagally-mediated HCl and intrinsic factor secretion (parietal cells)
    • does not block vagally-mediated gastrin secretion (G cells) because mediator of vagal effect is gastrin-release peptide (GRP), not acetylcholine (ACh)
  • Gastrin
    • ↑ gastric H+ secretion by 2 mechanisms
      • (1) gastrin stimulates enterochromaffin-like (ECL) cells in gastric mucosa to release histamine, which diffuses to nearby parietal cells and binds H2 receptors, stimulating H+ release (primary mechanism)
      • (2) gastrin binds CCKB receptors on parietal cells, stimulating H+ release (secondary mechanism)
 

Please rate topic.

Average 5.0 of 3 Ratings

Topic COMMENTS (0)
Private Note