• Atropine
    • blocks vagally-mediated HCl and intrinsic factor secretion (parietal cells)
    • does not block vagally-mediated gastrin secretion (G cells) because mediator of vagal effect is gastrin-release peptide (GRP), not acetylcholine (ACh)
  • Gastrin
    • ↑ gastric H+ secretion by 2 mechanisms
      • (1) gastrin stimulates enterochromaffin-like (ECL) cells in gastric mucosa to release histamine, which diffuses to nearby parietal cells and binds H2 receptors, stimulating H+ release (primary mechanism)
      • (2) gastrin binds CCKB receptors on parietal cells, stimulating H+ release (secondary mechanism)

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