• May be hot or cold 
    • hot signifies thyroid hormone production with 131I uptake
    • cold signifies no thyroid hormone production
  • Cause depends on gender and age
    • men
      • majority are malignant
    • women
      • majority are benign cysts or follicular adenomas
      • minority are malignant
    • children
      • majority are maligant
  • Large increase in malignancy potential if patient has previous exposure to ionizing radiation
  • Fine needle aspiration 
  • Thyroid hormone studies

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