Overview Adrenal Cortex and Medulla Primary Regulatory Control Anatomy Secretory products Renin-angiotensin Zona glomerulosa Aldosterone ACTH, hypothalamic CRH Zona fasciculata Cortisol and sex hormones ACTH, hypothalamic CRH Zona reticularis Sex hormones (e.g. androgens) Preganglionic sympathetic fibers Medulla Catecholamines (Epi, NE) Glomerulosa (salt), fasciculata (sugar), reticularis (sex) "The deeper you go, the sweeter it gets." Adrenal Circulation Both the left and right adrenals receive arterial blood supply in the same fashion paired superior suprarenal arteries - derived from inferior phrenic arteries paired middle suprarenal arteries - derived directly from abdominal aorta paired inferior suprarenal arteris - derived from the adjacent renal arteries The left and right adrenals have differing venous drainage left adrenal venous drainage is through the left adrenal vein to the left renal vein and finally to the IVC right adrenal venous drainage is through the right adrenal vein to the IVC Recall the same pattern for the left and right gonadal artery/vein Selected Pathology Pheochromocytoma Neuroblastoma Conn's syndrome Cushing's syndrome Addison's disease