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Introduction
  • Characteristics of small vessel vasculitides WITH immune complexes
    • contain immune complex deposits
  • Examples include
    • cryoglobulinemia
    • Henoch-Schonlein purpura (HSP)
    • infectious vasculitis
  • Overview of all vasculitides  
Cryoglobulinemia
  •  Overview
    • vasculitis affecting skin, GI, and renal systems
      • no joint involvement
    • relationship to HCV, type I membranoproliferative glomerulonephritis
    • antibodies that condense at decreased temperature
  • Presentation
    • Raynaud's phenomenon
    • palpable purpura
  • Epidemiology
    • adults
Henoch-Schonlein Purpura
  •  Overview
    • most common form of childhood systemic vasculitis
    • vasculitis affecting skin, GI, kidney, and joints due to IgA immune complex deposition  
      • lesions of same age
    • commonly follows URI
  • Presentation 
    • skin rash on buttocks and legs
      • palpable purpura
    • arthralgia
    • GI symptoms
      • intestinal hemorrhage
      • abdominal pain
      • melena
  • Epidemiology
    • children and young adults
  • Complications
    • Glomerulonephritis and ESRD 
    • More common in adults
Infectious Vasculitis
  •  Overview
    • vasculitis affecting skin
    • result of immune reaction to a pathogen
      • e.g., Rickettsia rickettsii (RMSF)
  • Presentation
    • RMSF involves petechiae on extremities that spreads to the trunk
  • Epidemiology
    • no age specificity
 

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