• Liver
    • receives highest percentage of systemic cardiac output
  • Kidney
    • receives highest blood flow per gram of tissue
  • Heart
    • unlike other organs, the heart receives its blood supply during diastole
      • 90% of blood flow through coronaries is during diastole
      • as the heart rate increases, the amount of time spent in diastole is relatively decreased  
    • extracts approximately 100% of oxygen in coronary circulation
      • largest arteriovenous oxygen difference
      • an increase in oxygen demand is supported by an increase in coronary blood flow, not an increase in extraction of oxygen from blood like in other organs

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