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Overview
  • Length-tension relationship in cardiac muscle
    • cardiac muscle fiber stretching
      • contractility ∝ end-diastolic volume (EDV)
        • ↑ length of cardiac muscle fibers (EDV)  → ↑ force of contraction (contractility)
          • EDV aka preload
  • Contractility (ionotropy)
    • intrinsic ability of myocardial cells to develop force
  • Positive ionotropic effects 
    • agents that produce an increase in cardiac contractility
      • circulating catecholamines
      • sympathetic stimulation
      • digitalis
  • Negative ionotropic effects
    • agents that produce a decrease in cardiac contractility
      • myocardial infarction (MI)
      • congestive heart failure (CHF)
      • pharmacologic depressents
 

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