Overview Characterized by triad of focal necrotizing vasculitis necrotizing granulomas in the lung and upper airway necrotizing glomerulonephritis Affects small vessels Symptoms hemoptysis hematuria perforation of nasal septum chronic sinusitis otitis media mastoiditis cough dyspnea Findings c-ANCA is a strong marker of disease chest x-ray may reveal large nodular densities hematuria and red cell casts Treatment cyclophosphamide corticosteroids