Psychiatric Drug Introduction Psychiatric medications can be broken down into the following categories Antidepressants Antipsychotics Bipolar Medications Anxiolytics Overview Drugs venlafaxine duloxetine Mechanism inhibit 5-HT and NE reuptake duloxetine has > blockade on NE serotonin norepinephrine reuptake inhibitors (SNRIs) leads to increased descending inhibition of pain signals Clinical use depression generalized anxiety disorder venlafaxine diabetic peripheral neuropathy duloxetine Toxicity MC is ↑ BP, stimulant effects due to ↑ in NE sedation nausea