Snapshot A 3-year-old boy is brought to the pediatric emergency department for intractable diarrhea. His symptoms initially began with him complaining of nausea and then having 2-3 episodes of emesis. His diarrhea is described as watery with no evidence of blood in the stool. The patient recently started attending daycare and has not been up to date on his vaccinations. His temperature is 102°F (38.9°C), blood pressure is 65/44 mmHg, pulse is 120/min, and respirations are 22/min. Physical examination is unremarkable. Stool studies are remarkable for rotavirus based on the enzyme-linked immunosorbent assay. Introduction Classification a non-enveloped, double-stranded RNA virus coltivirus Colorado tick fever rotavirus fatal diarrhea in children Diseases Bunyaviruses Virus Presentation Diagnostic Studies Treatment Coltivirus Mainly transmitted by the Rocky Mountain wood tick (Dermacentor andersoni) Symptoms headache nausea vomiting chills myalgias Physical exam fever can be biphasic having a fever for a few days, no fever, and then reappearing petechiae or a maculopapular rash Real-time polymerase chain reaction (RT-PCR) Supportive treatment (e.g., managing fever) Rotavirus Symptoms vomiting non-bloody and watery diarrhea Physical exam fever Testing the stool with immune-based assays (e.g.,enzyme-linked immunosorbent assay) and nucleic acid testing (PCR) Supportive treatment (e.g., repleting volume loss) Rotavirus vaccine as a preventative measure in all children except in patients with intussusception severe combined immunodeficiency Real-time polymerase chain reaction (RT-PCR)